28-31 These findings imply that there might be a common central pathogenesis and pathophysiology for these disorders
Ethics declarations Ethics approval and consent to participate The animal study was reviewed and approved by Experimental Animal Center of Wenzhou Medical University (Approval ID: wydw2022-0032)
Additional water-mediated hydrogen bonding between PDE1B inhibitors (e.g., pyrazolo-pyrimidone and quinazoline cores) and residues such as Q421, Y222, and H373 further enhances binding affinity
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Molecular weight: ~1419.55 g/mol
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