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The glucagon component adds a dimension of metabolic activation that the other compounds simply do not possess
2002;186(5 Suppl Understanding):S256-261
They are the medication doing what it is designed to do
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Upon activation of the GLP-1 receptor, cAMP levels increase, which activates the cAMP response element-binding protein (CREB) ( Furthermore, GLP-1R activation increases cAMP and alters downstream signaling pathways, including PKA, PI3K, PKC, and AKT, all of which contribute to its neuroprotective effects (Zhou et al., 2019)
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