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The Journal of biological chemistry

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To correct for this, we performed RNA-seq analysis of hypothalami obtained from animals treated with daily injections of either GLP-1MK-801 or a dose of semaglutide that was equipotent in terms of weight-lowering efficacy over 5 days of treatment, that is, mice had achieved a comparable weight loss and reduction in food intake as that of GLP-1MK-801-treated mice (Extended Data Fig

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That exceeds anything achieved by semaglutide or tirzepatide in comparable time frames