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However, obesity also appears to play an independent role in CKD risk and progression by triggering increased inflammatory signaling, oxidative stress, and gut microbiome disturbance, as well as premature cellular aging and dysfunction

Lipid Peroxidation Lipid peroxidation is a cascading chain reaction wherein by-products, such as radicals derived from fatty acids, interact with other free fatty acids, resulting in the formation of lipid peroxides (LPOs) (Einor et al

Some side effects (like nausea) are dose-dependent and might be milder at low doses, but others, like how it blunts appetite, could still lead to inadequate nutrient intake or a loss of lean muscle mass (called sarcopenia) if someone is losing weight without proper diet management

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