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In a perivascular adipose tissue inflammation model, macrophages deficient in SIRT3 exhibited a metabolic switch from oxidative phosphorylation to glycolysis, resulting in lactate accumulation and subsequent promotion of NLRP3 inflammasome activation and IL-1 secretion (133).In summary, the regulation of the NLRP3 inflammasome by lactate is not unidirectional
Yi L, Maier AB, Tao R, et al
Enzymology of cytosolic glutathione S-transferases [PMID: 8068560] Laboratory literature summary: Enzymology of cytosolic glutathione S-transferases
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Coadministered cagrilintide and semaglutide in adults with overweight or obesity
BPC-157 supports gut and tendon recovery, while TB-500 enhances muscle repair, mobility, and joint health
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