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In other words, the likelihood of having one or both of the MTHFR polymorphisms, as well as the frequency of variants (alleles) of the MTHFR gene, were not found to be more prevalent in those who have autoimmune thyroid disease compared to those who do not
A person can carry an MTHFR or COMT variant and still have adequate current methylation, while another person with no major variant can develop low SAM, elevated SAH or impaired glutathione production
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