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References Homma Y, Akiyama Y, Tomoe H, et al

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Semaglutide earned its formulary position based on the SUSTAIN clinical trial program, which demonstrated consistent A1C reductions of 1.2% to 1.8% across doses and comparators [1]

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This sequential approach serves two purposes: first, to eliminate immortal time bias by properly aligning treatment initiation with follow-up start (T0) and, second, to maximize statistical power by allowing individuals to contribute data across multiple trials

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First try reducing sodium intake, increasing potassium-rich foods, and ensuring adequate hydration

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