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Phase 2 is hypothesis-generating

In preclinical models, this therapy demonstrated a remarkable 100% survival rate, significantly outperforming steroids, which had a mortality rate of 45 %

Each group experienced two severe hypoglycemia events, and no cases of diabetic ketoacidosis were reported

There is also the argument that although we are replacing the human insulin normally produced by the beta-cells with injections of synthetic insulin, doing so can never completely mimic normal physiology

Quick Answer: GLP-1 medications typically cause modest blood pressure reductions of 2-6 mmHg, but some patients may experience symptomatic low blood pressure, particularly when combined with antihypertensive medications, significant weight loss, or dehydration from gastrointestinal side effects