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Abstract 13840: safety outcomes from a first-in-human study of a novel investigational monoclonal antibody, REGN5381, an agonist to the natriuretic peptide receptor 1
Xie, Y., Liu, X., & Zhou, P
This is one sure way to know this drug is beginning to function
These effects are attributable to redox regulation by SFN, since (i) SFN induced ROS and in parallel GSH depletion in primary human T-cells and (ii) thiol-containing antioxidants abolished the immunosuppressive effect of SFN
When that happens, she explains, the goal isnt to stop treatment but to adjust it
Most importantly, sulfur is needed for glutathione production
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