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(PubMed) Reszka E, Jablonska E, Gromadzinska J, Wasowicz W

10.1073/pnas.1313753110 7 BrutigamL.SchtteL

Subsequently, through the action of divalent metal transporter 1 (DMT1), Fe 2+ enters from the endosomes to the labile iron pool (LIP) in the cytoplasm [71]

co-administration of fungal -glucan has been reported to mitigate therapy-induced leukopenia and immune suppression, improving patient recovery (141)

This doesn't mean it's unsafe it means it hasn't gone through the specific regulatory pathway the FDA requires for approved drugs

IGF-1 elevation from full HGH use is associated with increased cell proliferation risk, fluid retention, and carpal tunnel syndrome at therapeutic doses