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While tempting, always inject into bare clean skin for accuracy and safety
We examine the role of receptor binding kinetics and -arrestin-biased signaling in the observed trafficking profiles, identifying a linked set of agonist characteristics optimally suited for insulin secretion, not shared by GLP-1R agonists in the current clinical use
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Bias-engineering at the extracellular domain spatially removed from the G protein interface is therefore a structurally plausible and largely unexplored design space for next-generation agonists
Salas Whalen about dose escalation, she and I shared the same advice for our patients
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