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In Study 2 (NCT00553787), patients with overweight or obesity were randomized to receive 1 year of treatment with placebo (N=994), phentermine and topiramate extended-release 7.5 mg/46 mg (N=498), or phentermine and topiramate extended-release 15 mg/92 mg (N=995) in a 2:1:2 ratio

Am J Surg Pathol 34:262270

Improves bone density GHRP-2 enhances bone mineralisation, potentially reducing the risk of fractures and osteoporosis

Semaglutide is also available as Wegovy, which is approved as a weight-loss drug

To put this in perspective, most approved migraine preventive medications reduce monthly headache days by 2 to 4 compared to placebo

This months update addresses once-weekly semaglutide in adolescents with obesity