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PMC 5203687

Phase 2 trials used once-weekly subcutaneous injections ranging from 1 mg to 12 mg, with higher doses associated with greater weight reduction but more gastrointestinal side effects

Most physicians recommend introducing one compound before the other rather than starting both simultaneously

GIP suppresses macrophage-dependent inflammation, whereas GLP1 reduces gut inflammation through its receptor on intraepithelial lymphocytes

Patients with chronic inflammatory arthritissuch as RA or psoriatic arthritissometimes show reduced inflammation within weeks of starting GLP-1 medications, even before major weight loss occurs

Research on muscle protein synthesis shows that your body can only use so much protein at one sitting for muscle building purposes