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Nevertheless, oxyntomodulin can be cleaved by DPP-4 in vitro (36, 56), and in animal studies, the anorectic effects of exogenous oxyntomodulin are increased after DPP-4 inhibition (56), while DPP-4-resistant oxyntomodulin analogs have been associated with improved glucose tolerance, reduced food intake, greater energy expenditure, and weight loss (57, 58)
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moreover, they witnessed considerable improvements in blood pressure and other areas of physical functioning
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Recurrent nocturnal hypoxic episodes promote oxidative stress and inflammatory activation, characterized by elevated TNF- , IL-6, and C-reactive protein levels (35)
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