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Nonclinical study design should prioritise models with metabolic profiles and target engagement characteristics that closely resemble those of humans to ensure translational relevance and regulatory alignment
[16] [17] Weight loss patterns vary considerably among individuals, and temporary plateaus are normal physiological responses that don't always necessitate dose changes
Dong H, Yuede CM, Coughlan CA, Murphy KM, Csernansky JG
Legacy effect of intensive glucose control on major adverse cardiovascular outcome: systematic review and meta-analyses of trials according to different scenarios
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