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Free heme is known to scavenge NO, potentially exacerbating the NO deficiency observed in G6PD-d and leading to vasoconstriction, increased vascular permeability, uptake of LDL, immune cell recruitment, and accelerated oxidation of LDL 60
Indeed, one of the poorly discussed limits of cystine transport study in vitro is the fact that the commonly used culture media contains exclusively oxidized form of cysteine
& Cashmere, K
Corpas, E., et al
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