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The mechanism involves inhibition of catechol-O-methyltransferase (COMT), which extends norepinephrine activity and slightly increases metabolic rate
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To understand how this evolving market might play out, this paper will address the following questions: What is the current state of the incretin mimetic market in diabetes and obesity, and how did we get here
Prespecified subgroup analyses were stratified by duration of GLP1-RA or DPP4i use (at least 6-months, 1-year, and 2-years of use) within their respective groups
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