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GLP-1s are usually not recommended for people who: Have severe gastrointestinal issues, such as gastroparesis Have an intolerance or allergy to GLP-1s Are pregnant or breastfeeding Have a personal or family history of rare forms of thyroid cancer called medullary thyroid cancer or multiple endocrine neoplasia type 2 Behavioral health is an important consideration before starting GLP-1 medications

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The 5-day spacing between injections reflects the pharmacodynamics of how MOTS-c signals at the mitochondrial level