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The LEADER trial showed a 13% reduction in major adverse cardiovascular events over 3.5 years

Following the aggregation of FcRI IgEallergen complexes and the activation of Src family kinases (such as Fyn, Lyn, and Syk), downstream signaling molecules (such as LAT and SLP-76) are phosphorylated and activated

A nasal spray was tried

In Phase 2 trials, dosing began at 2 mg once weekly subcutaneously, with incremental increases at approximately 4-weekly intervals up to 12 mg

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