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Key Findings: Most common: Nausea (43%), diarrhea (33%), vomiting (21%) Unique to retatrutide: Dysesthesia (20.9% @ 12mg in TRIUMPH-4, 8.8% @ 9mg) Discontinuation rate: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 (general obesity population) compared to semaglutide 6.9%, tirzepatide 6.2% Good news: Most side effects peak during dose escalation and improve significantly after week 16 Management: Slow titration, dietary modifications, and proper timing dramatically reduce severity Understanding the Three Categories of Side Effects 1
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and women with polycystic ovary syndrome)
The prescription brand name for semaglutide is Ozempic if its prescribed for patients with type 2 diabetes
The role of GLP-1R in neuropathic pain, particularly diabetic neuropathy, is supported by preclinical evidence
Entries into a sleep diary are made in the morning immediately after waking and allow for estimates of sleep parameters such as the time between going to bed and falling asleep, time to waking after falling asleep, total sleep time, total time in bed, sleep efficiency, and overall satisfaction
