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Dehydration, intense workouts, or illness can quickly deplete electrolytes, leading to fatigue or cramps

Pooyandjoo, et al., The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials, Obes Rev, Oct 2016, 17(10):970-6

doi:10.1073/pnas.0913154107

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unfortunately, this comparison was a qualitative one and no quantitative measurement of melanin in histopathological sections could be done