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Central Sensitization & Neuropathic Signaling Gabapentin reduces excitatory neurotransmitter release (including glutamate), it decreases neuronal hyperexcitability
Gamma-glutamylcysteine (GGC) is a naturally occurring peptide composed of glutamic acid, cysteine, and glycine
224 Although, there is evidence to suggest that islet alpha-cells can secrete GLP-1 during healthy circumstances and that this secretion becomes elevated during diabetic/disease conditions, whether these cells secrete GLP-1 and the physiological relevance of this remains unclear
Patients in the early weeks of GLP-1 therapy (when GI side effects are most common) should be especially cautious
DOI: 10.1111/nmo.14181
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