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High-dose ascorbic acid (500mg+) can trigger transient gastric irritation even when injected intramuscularly because the absorption spike affects systemic pH

SIRT6 inhibits hypoxia-induced pulmonary arterial smooth muscle cells proliferation via HIF-1/PDK4 signaling

[10] [18] [19] Enhancement of dopaminergic neurotransmission is observed in the hypothalamus, striatum, ventral tegmental area, nucleus accumbens, and other regions

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Repeated cocaine self-administration alters processing of cocaine-related information in rat prefrontal cortex