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South African Medical Journal , 106(8):782-786
92 In this mechanism, bacterial GSH is an essential cofactor, and mutants that are defective in GSH biosynthesis cannot inactivate fosfomycin, even though they possess the resistance gene
The vacuolar H + -ATPase is a multisubunit complexes that are members of the larger V-ATPase family of proton transporters and are related to the F-type ATPases exemplified by the F0F1-ATPase (complex V) of the oxidative phosphorylation process
What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect
Protection du glutathion : Empche sa dgradation prmature par les enzymes digestives
