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Detailed analyses of the kinetics of sensor recovery (Supplementary Figure S3) revealed that the resulting recovery curve can be described by three parameters: (i) an initial lag phase that correlates with the maximal E GSH reached upon diamide treatment and thus represents the sensitivity of the cellular redox environment towards oxidant treatment

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Whilst this NMA addresses a range of efficacy and safety outcomes, the primary goals of the studies included in the NMA were to assess weight reduction and safety outcomes, rather than cardiovascular, hepatic or renal factors

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Patients were monitored for a maximum of 24 months from treatment initiation until the initial diagnosis of a neuropsychiatric outcome, death, loss to follow-up, or end of study