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It's why researchers are now investigating whether GLP-1 weight loss medications, such as Ozempic (semaglutide) and Zepbound (tirzepatide), in combination with hormone replacement therapy, can help women maintain a healthy size and treat symptoms in midlife

The consistently higher HbA1C levels in the GLP-1 RAs group throughout the study suggesting the pleiotropic effects of GLP1RAs additional to glucose lowering effect 21

Birth control pills may not work as well while using compounded tirzepatide

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hybridus is widely recognized as the most likely ancestor, its polyphyletic nature complicates this interpretation (Snchez-del Pino et al., 2025