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In 2009, Richard DiMarchi and Matthias H Tschp's team reported that dual agonists targeting GLP-1R/GCGR did better in weight loss compared to GLP-1RA [10]
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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