can you take creatine while on semaglutide Mayo Clinic Preventing Muscle Loss With Creatine on Retatrutide: Interactions, Safety,

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These GLP-1 drugs are commonly prescribed for diabetes management and weight loss

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[28] Normally, this would be a concern, since insulin can be considered the "energy storage hormone", but its appetite suppressive properties (due to delayed gastric emptying) tilt the scales towards more weight loss -- the point where it's become more than just antidiabetic drug

Weight regulation is not controlled by a single switch