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Guideline 2: Maintenance Dosing Schedules After the first phase, patients move to a maintenance dosing schedule for vitamin B12 therapy

Across both healthcare systems, female patients underwent approximately 2.3 times more tests than male patients

NNMT is highly expressed in adipose tissue and plays a role in cellular methyldonor economy and nicotinamide processing

Clinical Evidence: Research shows high-dose B12 therapy can greatly improve neurological function in severe cases

However, experts agree that it is necessary for vegans to take a B12 supplement to ensure that enough of it is absorbed

Higher doses of vitamin B12 may be used to treat a clinically recognised deficiency