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Insulin resistance and insulin deficiency in the pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus : errors of metabolism or of methods

Vicente-Gutierrez C, Bonora N, Bobo-Jimenez V, Jimenez-Blasco D, Lopez-Fabuel I, Fernandez E, et al

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Starting at 2.5 mg weekly for four weeks, then increasing to 5 mg, then 7.5 mg, 10 mg, 12.5 mg, and ultimately 15 mg as needed and tolerated

Broader receptor activity can also lead to more systemic effects, which is why safety and side effects are often studied