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Talk to your clinician about whether a dose increase is actually necessary before making the jump

Inflammation is a well-recognized contributor to the pathogenesis of insulin resistance and type 2 diabetes

360 MSU crystals cause cellular damage and mediate inflammatory responses, such as prostaglandin, bradykinin, IL-1, IL-6, and TNF-a

Mima A, Yasuzawa T, Nakamura T, et al

Mild, localised injection site reactions that resolve within a few days typically do not require treatment discontinuation

Almost 40,000 of those reactions involved gastrointestinal issues, including reports of intestinal obstruction, small intestinal obstruction, paralytic ileus, gastric obstruction, and intestinal perforation