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Hepatic triacylglycerol accumulation and insulin resistance

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In PSC, the liver aberrantly expresses the corresponding ligands, MAdCAM-1 and CCL25, thereby promoting the recruitment of gut-primed lymphocytes and contributing to peribiliary inflammation and tissue injury [300, 301]

This natural compound is key for fixing and growing cells

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Astrocyte-specific genes (e.g., Gfap, Aqp4, Mat2a, Mafg , and DNMT3B ) have unique DNA methylation profiles that stabilize astrocyte identity upon the inflammation (Wheeler et al., 2020)