This chronic lipid burden impairs mitochondrial function and elevates reactive oxygen species (ROS) levels, 11 causing oxidative stress and hepatocellular injury
Clinical trial data shows meaningful weight loss in the first 12 weeks of GLP-1 treatment, though results vary significantly based on starting weight, the specific medication, dose, dietary choices, and activity level
Another important consideration when evaluating the impact of these medications on bone health outcomes is the sustainability of GLP1Ra use as weight regain following cessation of treatment is expected (Waters et al., 2013
Helical peptides that are known to play key roles in maintaining metabolic homeostasis include, among others, glucagon (GCG) and glucagon-like peptide-1 (GLP-1), which signal and agonise the G-protein-coupled receptors (GPCR) GCGR and GLP-1R, respectively 1
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doi:10.1038/s41598-024-77218-8 66