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The ladder above is not a validated human dose
Read review Dihexa for Autism Spectrum Disorder (ASD) The Campbell rs1858830 MET promoter C-allele autism finding (the strongest mechanistic anchor to Dihexa pharmacology), the January 2026 mGluR5 PET 16-23% lower availability, the December 2025 DAYBUE STIX (trofinetide) Rett approval, the March 2026 FDA leucovorin decision (CFD only, not autism), the 270,701 NHS open referrals breaching NICE NG142, and the ~700,000 UK autistic population
Mechanistically, their antioxidant activity stems from their ability to trap acyl chain-carrying peroxyl radicals in lipid bilayers
Plis SM, et al
But they engage different receptor systems , sit at different evidence tiers , and carry very different regulatory status
