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The functional consequence in animal models is synergistic rather than additive GH output: GHRH-R priming increases the pool of releasable GH vesicles, and GHS-R1a co-stimulation then drives a larger amplitude pulse than either receptor produces alone

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doi: 10.1038/s41467-018-06048-w 61 ZhaoYChenFWuWSunMBilottaAJYaoSet al

However, research on ipamorelin is limited and the FDA has not approved it yet