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The damage from freeze-thaw cycles comes from repeated freezing and thawing of the same solution, where ice crystals form, melt, reform, and melt again, each cycle physically stressing the peptide molecules
As a peptide, BPC-157 also carries a theoretical potential for immunogenicity (antibody formation) with repeated dosing, which has not been studied longitudinally in dogs
doi: 10.2147/DDDT.S426870 75
Precautions for Cyanocobalamin General Precautions Vitamin B 12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord
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Michaowicz J, Wuka A, Bukowska B
Experience in the surgical management of 82 symptomatic herniated thoracic discs and review of the literature
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