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Regul Pept 106(13):8995 Schirra J, Houck P, Wank U, Arnold R, Gke B, Katschinski M (2000) Effects of glucagon-like peptide-1 (736) amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans
BCL2, B-Cell Lymphoma 2
whether anything similar occurs in humans is unknown Signs It's Working Laboratory markers (research) Fewer SA--gal positive (senescent) cells [2] Lower aging markers p16 and p21 [3] Less DNA-damage signal (gamma-H2AX) [3] Higher apoptosis signals: BAX and cleaved caspase-3 up, BCL-2 down [3] Animal/physical outcomes (research) Regrown fur density in aged mice [1] Better kidney function [1] Improved running endurance and grip strength [1] Reduced artery stiffness [3] What people report after a cycle More energy and better recovery in the weeks following a cycle Improvements in skin quality and tone Better joint comfort and mobility A general sense of "feeling younger" between cycles Not Seeing Results
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Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]
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