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Formalin-fixed, paraffin-embedded tissue sections were deparaffinized, rehydrated and subjected to antigen retrieval as described in the SenTraGor staining section
In this instance, the concentrations of doxorubicin required to induce a deleterious GSH response fall firmly outside of the therapeutic ranges of circulating doxorubicin reported 40
Oncogene 23 (54), 87438755
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This counterintuitive finding suggested that while FOXO4 is involved in the senescence program, it also helps maintain the viability of senescent cells, potentially contributing to their accumulation [2]
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