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likewise, compensatory hyperinsulinemia in the setting of insulin resistance could also contribute to anomalies in vaso-reactivity, angiogenesis, and fibrosis implicated in CKD and atherogenesis [53]

By scavenging ROS, antioxidants can potentially impair neutrophil and macrophage function, thereby weakening the host defence mechanisms critical in septic patients (Galley, 2010)

Contrastingly, in adults, mutations are often identified in just one of the two alleles, hinting at a haploinsufficiency mechanism

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