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Notably, CNS GIPR antagonism produces body weight loss in obese mice and also extends the anorectic effect of a GLP-1R agonist
Additionally, traditional pharmacological treatments, such as disulfiram or naltrexone, often come with significant side effects or require strict rules when it comes to dosage and use schedules
The influencing factors of GLP-1 secretion mainly involve the following aspects: (1) Activation of related receptors
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