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Retinal pigment epithelial cells express a functional receptor for glucagon-like peptide-1 (GLP-1)

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Even without diabetes, the combined effects can cause lightheadedness or weakness

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DSIP has been investigated for possible modulatory effects on CRH signaling and downstream ACTH secretion

The maintenance frequency approach where intensive initial treatment transitions to reduced ongoing application (2-4 times weekly) provides middle ground sustaining benefits while minimizing costs and commitment intensity