Understanding peptide stability and delivery methods critical for efficacy
Proposed criteria for efficacious therapeutics in PMS include penetration across the bloodbrain barrier, antagonism of compartmentalized lymphocytes and microglia/macrophages, and amelioration of oxidative stress
Sampling errors may pose a pitfall
Although mutations in PhyH are the primary cause of Refsum disease, the syndrome can also result from defects in the peroxisomal protein (PEX7) responsible for the import of PhyH into the peroxisome
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Radtke KK, Coles LD, Mishra U, Orchard PJ, Holmay M, Cloyd JC