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The palms and soles have unique features, like a lack of hair follicles and oil glands but many sweat ducts

moreover, the pro-inflammatory mediators these cells secrete delay the phenotypic transformation of macrophages from M1 to M2, hinder the establishment of an anti-inflammatory microenvironment, and thereby promote fibrosis and ectopic ossification (116)

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These findings imply that emodin protects hepatocytes from APAP-induced liver damage by activating Nrf2-mediated antioxidant stress pathways, inhibiting the NLRP3 inflammasome, and downregulating the cGAS-STING signaling pathway (Shen et al., 2022)