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prausnitzii regulates immune cell activity by producing a fatty acid amide hydrolase (FAAH) that converts oleoylethanolamide (OEA) into N-acyl amino acids (NAAAs) to activate immune-related receptors such as GPR132 and GPR31, thereby attenuating local immune overresponses, increasing immune homeostasis and protecting the intestinal microenvironment 83

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ACA marketplace plans are also reducing access to GLP-1s for weight loss, with only 26 of the 300 carriers offering coverage, and overall coverage rates falling from 3.6 million enrollees in 2024 to 2.8 million in 2026

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