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In these populations, discontinuation of GLP-1RAs before or during early pregnancy has been associated with greater gestational weight gain and, in some reports, less favorable pregnancy-related metabolic outcomes

In the STEP 1 trial, semaglutide 2.4 mg produced a mean body weight reduction of 14.9% over 68 weeks but the quality of that weight loss, including preserving lean mass and building healthy habits, determines how maintainable the result is

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That would pose intracranial pressure control as a brand-new, pharmacologically targetable pathway. Mild gastrointestinal side effects (mainly nausea and constipation) occurred in 38% of participants but did not lead to treatment discontinuation

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The clinical sites, sample sources (CENTER TBI [31, 41] and the CanTBI bank [30]), severity of TBI, health status of controls, time points and methods for characterizing lipid metabolism varied between trials and contributed to the observed differences