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When glutathione is depleted - as seen in autoimmune thyroid disease - HO accumulates, causing oxidative damage to thyroid follicular cells

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This activation sets off a cascade of events that influence appetite, digestion, and ultimately contribute to weight loss

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But 23% is still a meaningful step up from what semaglutide (Wegovy) achieves on its own, where the average tends to land around 14 to 15%