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8.4 Pediatric Use PEDIATRIC USE SECTION The safety and effectiveness of MOUNJARO as an adjunct to diet and exercise to improve glycemic control in pediatric patients 10 years of age and older with type 2 diabetes mellitus have been established
The most commonly reported side effects include: Nausea : Affecting 12% to 24% of patients with type 2 diabetes and 24% to 31% in weight management trials [1] [14] Diarrhea : 12% to 17% in diabetes trials and 18% to 23% in weight management trials Decreased appetite : 5% to 10% of patients Vomiting : 5% to 10% in diabetes trials and 8% to 12% in weight management trials Constipation : 5% to 7% in diabetes trials and 16% to 17% in weight management trials Dyspepsia : 5% to 9% of patients Abdominal pain : 5% to 9% of patients Alopecia (hair loss) : Reported in weight management trials These symptoms are typically mild to moderate in severity, occur most commonly during dose escalation, and tend to diminish over time as patients develop tolerance
Some breakfast cereals are also fortified with B12
Health authorities in Malta have warned against unauthorized products claiming to contain the weight-loss drug retatrutide, which is being sold online and through social media without approval
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In our transcriptome data, many genes known to be induced by the UPR mt , such as heat shock proteins Hsp60A and Hsc70-5 [50, 60, 61], glutathione-S-transferases and genes involved in glycolysis, translation, heme biosynthesis and OXPHOS assembly, were upregulated when UQCR-C1 was knocked down
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