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In animal models, GLP-1 receptor agonists reduce cocaine, methamphetamine/amphetamine, and nicotine-related behaviors, including drug taking, motivation to use, and relapse-like seeking
This method is often preferred by those looking for maximum impact with lower, more targeted doses
, 7 Pountos I, Panteli M, Walters G, Bush D, Giannoudis PV
Following these data, deletion of endogenous Mecp2 with a specific small hairpin RNA interference reduced spine density after 96 h of expression and decreased the number of mature-shaped dendritic spines [374]
although benign, it can be socially bothersome
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