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however, the specific upstream molecular regulators of this effect warrant further investigation
Further studies indicate that inhibiting the proprotein convertase Furin sustains the pro-inflammatory phenotype of CAR-M, enhances its phagocytic capacity against breast cancer cells and patient-derived organoids, and ameliorates the immunosuppressive microenvironment through secretion of T-cell-activating factors (276)
Clinicians should also consider potential interactions with cyclosporine, levothyroxine, warfarin, and antiepileptic drugs
Pizzurro DM, Dao K, Costa LG
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