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The AKT-induced phosphorylation of FoxO proteins generates the binding sites for the 14-3-3 proteins which induce the accumulation of FoxO proteins into the cytoplasm thus preventing their transcriptional activity

Diarrhea and gas are very common side effects

Activated caspase-4/5/11 specifically cleaves GSDMD to release the N-terminal pore domain (NT), leading to cell membrane perforation and pyroptosis (105)

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And it helps maintain overall cell health , buffering tissues against oxidative stress and inflammation